Acetaminophen vs Ibuprofen vs Aspirin

When it comes to immediately addressing minor ailments, these painkillers are the first line of defense: paracetamol, ibuprofen, and aspirin. However, the selection of painkillers is not a box of chocolates. The wrong choice or dosage can lead to complications or more serious problems. The problem is that according to studies, almost half of Americans can’t distinguish the differences among the three and most of them are likely to take the first painkiller available.

Here is a quick comparison of the three to help you avoid the risk of taking the wrong painkiller.


Acetaminophen or paracetamol is considered as the most generic painkiller. It is used for common colds or flu and can relieve or ease pain from headaches and muscle pains. It can also help with menstrual pains. However, acetaminophen is often the jack of all trades: it can be used for many minor ailments, but ibuprofen and aspirin can be the better option for certain needs.

The main benefits of taking acetaminophen, which is known to be present in Tylenol, are that it can be taken with an empty stomach and is safe to combine with other medication or supplements. One just needs to be careful with the dosage because acetaminophen can be an ingredient in certain drugs.


As a non-steroidal anti-inflammatory drug, ibuprofen is recommended for relief from inflammation brought by rheumatic or muscular pain. Still, this painkiller is mainly marketed for menstrual cramps. Known brands such as Motrin, Midol, and Advil have ibuprofen.

The side effects of ibuprofen include dizziness and drowsiness. It can be combined with medicines, but it is best to consult with a doctor or pharmacist because the wrong intake can still lead to kidney or heart problems.


Also a non-steroidal anti-inflammatory drug, aspirin can be used to alleviate inflammation related to muscle and rheumatic pain. It can also be used for aches, sprains, and sore throat. What is unique about aspirin is that it can be used to thin out platelets and prevent blood clots.

It is important to remember that aspirin should be taken more carefully. It is a stomach irritant and it doesn’t mix well with medicines and supplements. Also, it is not recommended for people with certain conditions such as asthma, ulcer, high blood pressure, and liver and kidney diseases.

For professional pharmaceutical advise and efficient delivery, give us a call here at Kearney Park Compounding Pharmacy and discover how compounding can help you and your family here in the Dallas Fort Worth Texas area.


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